ARTICLE
APOBEC3G expression and HIV-1 infection in Burkina Faso
- Journal of Public Health in Africa , 9 (3) : 903-913
Lien de l'article :
https://doi.org/10.4081/jphia.2018.907
Discipline :
Sciences biologiques
Auteur(s) :
Tegwinde Rebeca Compaore, Serge Theophile Soubeiga, Abdoul Karim Ouattara, Damehan Tchelougou, Cyrille Bisseye, Didier Romuald Bakouan, Issaka Compaore, Augustine Dembele, Albert Theophane Yonli, Dorcas Obiri-Yeboah, Wendkuuni Florencia Djigma, Jacques Simpore
Auteur(s) tagués :
OUATTARA Abdoul Karim
SIMPORE Jacques
Renseignée par : DJIGMA Wendkuuni Florencia
Résumé
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.
Mots-clés
HIV-1, APOBEC3G mRNA, rs8177832, rs35228531, rs6001417, Burkina Faso