Role of microRNA-33a/b in Cholesterol Metabolism in Type 2 Diabetic Patients in Ouagadougou, Burkina Faso
- Advances in Biochemistry , 7 (4) : 71-76
Résumé
Abstract: MicroRNAs (miRNAs) are small endogenous RNAs approximately 22 nucleotides involved in the regulation of several cellular metabolisms including cholesterol metabolism. The objective of this study was to measure miRNAs 33a and 33b in type 2 diabetics to evaluate their impact on the lipids levels and prevalence of dyslipidemia. The study population profile was 45 subjects including 30 type 2 diabetic patients and 15 healthy controls. The lipids tests were performed using an automated Spintech 240 Biolis analyzer and the microRNAs (33a and 33b) by applied biosystems 7500 Fast Real Time PCR System using the TaqMan® MicroRNA Assay kit. The prevalence of dyslipidemia was higher in
miRNA-33a positive subjects than miRNA-33a negative (p
Mots-clés
Type 2 Diabetes, miRNA-33a / b, Dyslipidemia, Ouagadougou